Postdoctoral position in biomicrofluidics - Spatially-resolved efficacy of quorum-sensing inhibitors in microchannel flows

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Project overview . This interdisciplinary project investigates the efficacy of quorum-sensing inhibitors (QSIs) in microfluidic models of bacterial biofilms. We aim to address antimicrobial resistance by developing novel approaches to prevent biofilm formation in mixed bacterial communities of Pseudomonas aeruginosa and Staphylococcus aureus , which are particularly problematic in cystic fibrosis patients. By combining advanced microfluidic techniques with expertise in drug development, we will evaluate how flow conditions affect QSI efficacy and biofilm properties, ultimately contributing to new therapeutic strategies against resistant infections. Research highlights. Develop and use microfluidic chips . Evaluate efficacy of QSIs under flow conditions that better mimic in vivo environments . Characterize mixed-species biofilms using imaging and analytical techniques . Contribute to the development of new therapeutic approaches for cystic fibrosis patients . Work at the interface of physics, engineering, chemistry, and microbiology . Research environment . The postdoctoral research will be conducted at the Institut de Mécanique des Fluides (IMFT) and at the Laboratoire de Génie Chimique (LGC), with experiments performed in a level 2 biosafety laboratory at the Centre Hospitalier Universitaire (CHU) de Toulouse. The candidate will benefit from state-of-the-art facilities and equipmen