Postdoctoral Researcher (M/F) in Cell and Molecular Biology – 24 months Role of the RNA Damage Response in Cellular Plasticity and Chemotherapy Resistance in Lymphomas

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Cellular plasticity is a major mechanism by which tumor cells adapt to microenvironmental constraints, particularly nutrient deprivation. In lymphomas, resistance to chemotherapy, including asparaginase-based treatments, is partly driven by the activation of molecular pathways that enable tumor cells to adapt to stress and maintain their survival. This project aims to characterize the signaling pathways and RNA Damage Response (RDR) mechanisms involved in cellular plasticity and therapeutic escape in lymphoma. In particular, we will investigate how alterations in RNA integrity and function are sensed and integrated by tumor cells to remodel their cellular state, metabolism, and survival capacity in response to treatment. The overall objective is to identify the molecular mechanisms linking cellular stress, plasticity, and therapeutic resistance, thereby uncovering new cellular and metabolic vulnerabilities that could be exploited to develop targeted therapeutic strategies in oncology. With a PhD in cellular and molecular biology, the successful candidate should have a strong scientific background, both theoretical and practical, in cellular stress signaling pathways, regulation of ribosome biogenesis, translation, and cell fate, as demonstrated by scientific publications. The successful candidate is expected to demonstrate a high degree of autonomy, rigor, excellent organizational s