Postdoctoral researcher position (M/F) - 3 years – NF-kappaB, Proteasome, Cancer and Immunology

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description We are recruiting a postdoctoral researcher for a 3-year position to work on a project aimed at identifying new therapeutic strategies targeting the NF-κB pathway in two hematological malignancies: multiple myeloma and mantle cell lymphoma . This project is funded by the French National Cancer Institute (INCa). Our recent work has led to the identification of new NF-κB regulators associated with the ubiquitin-proteasome system , as well as the characterization by mass spectrometry of the components of supramolecular complexes discovered in the laboratory that are involved in NF-κB activation. We have also demonstrated their constitutive presence in tumor cells. Compounds identified through a pharmacological screening approach represent promising therapeutic leads, including in models of bortezomib-resistant cell lines. The project combines a fundamental research axis , aimed at gaining a better understanding of the molecular mechanisms involved in the regulation of the NF-κB signaling pathway induced by inflammatory cytokines, with an applied cancer research axis focused on identifying therapeutic targets in multiple myeloma and mantle cell lymphoma . The project may also extend to questions related to immunology, inflammation, and infection , taking advantage of the scientific environment of the CIMI and the laboratory's collaborations. The postdoctoral researcher will investigate: