Photochemical synthesis of anticancer compounds

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description In the frame of cancer treatment, chemotherapy is widely used, but it is impaired by resistance. development and by toxicity on healthy cells. New targeted therapies (tyrosine-kinase. inhibitors, ADC…) have led to the improvement of patient’s survival rates, but oncogenic targets. are not always well defined, and resistance may also occur, as do side-effects. We recently developed a straightforward synthesis of new fused quinoline derivatives by means. of a photoactivation step. These compounds exhibit antiproliferative activity through an. innovative bioactivation pathway we have just patented. Thanks to a grant from Inserm, we intend to exemplify these preliminary results through. numerous new promising chemical targets, some of which being patentable too. Collaborations with two partners strongly support this project: 1) Computational chemistry. (LPCT UMR CNRS 7019, same location as L2CM) and 2) Biologic evaluation (CRCLille, UMR. 1366 INSERM). References: Cortelazzo-Polisini, E. et al. J. Org. Chem. 2022, 87, 9699-9713. https://doi.org/10.1021/acs.joc.2c00748. Bruneau, V. et al. Chem. Eur. J. 2026, corrected proofs: https://doi.org/10.1002/chem.71696. Where to apply E-mail [email protected]. Requirements Research Field Chemistry » Organic chemistry Education Level PhD or equivalent . Skills/Qualifications. Ph.D. in organic chemistry (obtained less than 2 years ago