n.1 RESEARCHER according to art. 24, L. 240/2010 Department DMMT ad BIOS-07/A

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description The activity will focus on the metabolic adaptations of tumor and stromal cells and on the role of the tumor microenvironment in cancer progression.The objective will be to characterize the molecular and metabolic mechanisms governing the interactions among tumor cells,stromal cells,and the extracellular matrix using in vitro,ex vivo,and in vivo models.Particular attention will be paid to biochemical,biophysical,and structural alterations of the extracellular matrix and their influence on energy metabolism,metabolic fluxes,and functional interactions among cell populations within the tumor microenvironment.The mechanisms through which these alterations contribute to metabolic heterogeneity,tumor progression,and treatment response will be investigated to identify novel therapeutic targets and strategies.The research will also include the development of methods for the multiscale analysis of metabolism in cells,tissues,and organs by integrating cellular and molecular biochemistry,metabolic flux analysis,flow cytometry,bioinformatics,and functional assays with high-resolution imaging technologies.Confocal,multiphoton,and intravital microscopy will enable the investigation of metabolic dynamics,the subcellular localization of metabolic processes,the three-dimensional organization of tissues,and cell–matrix interactions.Fluorescent probes,biosensors,fluorescence lifetime imaging microsco