PhD in Computational Systems Biology / Bioinformatics (M/F)

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description As part of the PANDORA project, a PhD position is available at the Centre for Integrative Biology (CBI) in Toulouse, a joint CNRS–University of Toulouse unit dedicated to integrative biology at various scales. The successful candidate will join the Systems Biology group and will be supervised by Professor Anna NIARAKIS. Job description : Creation of a multi-scale predictive digital twin of the retina affected by age-related macular degeneration (AMD) (DC8). This PhD position forms part of the MSCA PANDORA doctoral network, which investigates the pathological mechanisms and optimisation of new drugs for age-related macular degeneration (AMD). Computational modelling enables researchers to integrate several types of biological data into a single framework, to test perturbations in silico, and to predict pathological mechanisms and responses to treatments before testing them in the laboratory. The PhD student will develop large-scale molecular interaction maps of retinal mechanisms linked to AMD and the complement system. They will convert these maps into executable Boolean models using the 'map-to-model' framework developed at the CNRS/UPS and INRIA, and then adapt the models to the specific conditions of AMD using omics data generated within the consortium. The models will then be integrated into an agent-based multi-scale model (ABM) to create a digital twin of the retina affected b