Entrepreneurial PhD position in Paris – Microfluidic Perfusion Instrument for Retinal Models

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Microfluidic Perfusion Instrument for Retinal Models . PANDORA is an MSCA Doctoral Network of 13 PhD students studying the role of the complement system in Age-related Macular Degeneration (AMD), the main cause of blindness in the elderly, and developing new ways to model and treat it. Your project is the development of a benchtop microfluidic instrument that keeps living retinal tissue alive outside the body for weeks. Unlike conventional static culture, where the medium is exchanged by hand every couple of days, your platform will recirculate the medium continuously through a closed loop, and you will build it from MIC's flow control technology, integrating sensors and feedback loops to give full control of the culture microenvironment. A key research question is how to recreate the low-oxygen conditions of the diseased retina, turning the platform into a disease model in its own right. You will validate it with consortium partners on retinal organoids and living retinal explants, including combination drug treatments, and evaluate its path to market. Place: based in Paris, 4 months of secondments within the consortium (Newcastle University, UK; University of Tübingen, Germany) . PhD awarded by: Sorbonne Université (Paris) . Research and development activities in brief . Design and develop a benchtop microfluidic perfusion instrument with continuous medium recirculation. Integrate