PhD in Computational Systems Biology / Bioinformatics (M/F)

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Job description : Creation of a multi-scale predictive digital twin of the retina affected by age-related macular degeneration (AMD) (DC8) . This PhD position forms part of the MSCA PANDORA doctoral network, which investigates the pathological mechanisms and optimisation of new drugs for age-related macular degeneration (AMD). Computational modelling enables researchers to integrate several types of biological data into a single framework, to test perturbations in silico, and to predict pathological mechanisms and responses to treatments before testing them in the laboratory. The PhD student will develop large-scale molecular interaction maps of retinal mechanisms linked to AMD and the complement system. They will convert these maps into executable Boolean models using the 'map-to-model' framework developed at the CNRS/UPS and INRIA, and then adapt the models to the specific conditions of AMD using omics data generated within the consortium. The models will then be integrated into an agent-based multi-scale model (ABM) to create a digital twin of the retina affected by AMD, simulating intercellular communication and tissue homeostasis. The digital twin will simulate the system disturbances studied experimentally at the network level: environmental stress conditions, different compositions of the extracellular matrix, gene inactivations and gain-of-function variants. The in silico pr