Postdoctoral Researcher

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Position Summary . A postdoctoral training position is available in the laboratory of Dr. Marek Napierala in the Department of Neurology at the University of Texas Southwestern Medical Center ( https://labs.utsouthwestern.edu/napierala-lab ). The Napierala laboratory has several exciting projects related to developing therapeutic strategies for neurodegenerative disorders that involve gene regulation, repeat instability, mitochondria fitness and function, neuron development and activity and biomarker discovery. A variety of model systems and experimental approaches are used for our projects, including induced pluripotent stem cell (iPSC) models, mouse models, genome editing, next-generation sequencing, genomics, transcriptomics, proteomics, molecular biology, biochemistry. Current projects funded by the National Institute of Neurological Diseases and Stroke (NINDS) include: 1) determining how somatic repeat expansions influence neurodegenerative phenotypes; 2) defining the molecular mechanisms underlying somatic instability of repetitive DNA sequences; and 3) determining how interruptions within repeat tracts influence cellular and tissue-level phenotypes. Candidates must hold a recent Ph.D. and/or M.D. degree. Experience in mammalian cell culture or working with mouse models of neurological disorders, along with proficiency in basic molecular biology techniques leading to publicati