Post-Doctoral position in photochemical synthesis of anticancer compounds (M/F)

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Chemotherapy is widely used in cancer treatment, but its effectiveness is limited by the development of drug resistance and toxicity to healthy tissues. Targeted therapies (tyrosine kinase inhibitors, antibody–drug conjugates) have improved patient survival. However, oncogenic targets have not been identified for all cancer types, and these therapies are also associated with the development of resistance and adverse effects. We have recently developed an efficient photochemical synthetic route to novel fused quinolines. These compounds have demonstrated promising antiproliferative activities through bioactivation mechanisms that we have recently patented. As part of an Inserm-funded project, we aim to expand this preliminary study to a broad range of additional promising structures that we have identified and that also have patent potential. The project benefits from two major collaborations: (1) Computational Chemistry (LPCT, CNRS UMR 7019, located near L2CM) and (2) Biological Evaluation (CRCLille, INSERM UMR 1366). The successful candidate will contribute to this broader research project. References :. Cortelazzo-Polisini, E. et al. J. Org. Chem. 2022, 87, 9699-9713. https://doi.org/10.1002/chem.71696 . Bruneau, V. et al. Chem. Eur. J. 2026, corrected proofs: https://doi.org/10.1002/chem.71696 . -Setup a library of compounds to be prepared and define priority order. -Achieve mult