Thèse en physique du vivant (M/F)

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Close mentoring: daily lab presence of your supervisor, a weekly one-to-one meeting and lab meetings. Hands on technical training: biomaterials, organ-on-chip engineering, live imaging, quantitative image analysis, active-matter physics. A welcoming team: a interdisciplinary environment within a well-equipped biophysics group with close links to the soft-matter and active-rheology experts of ILM. Collaborations: national and international. This project aims to study the role of activity and anisotropy in the mechanics of cellular monolayers. Activity is found in systems which are out-of-equilibrium. They consume energy at the microscopic level, such as ATP hydrolysis in cells, which allows them to generate active stresses, such as contractile forces in the acto-myosin network in cells. Anisotropy is found in systems which have elongated particles, or cells, leading to different properties along the X or Y direction. Traditional mechanical characterization of biological tissues considers them as passive and isotropic materials. This project will close this gap using a novel in vitro system: the microstretcher. The microstretcher is a microfluidic system which allows the application of tension at the tissue scale while manipulating the cellular activity and anisotropy (Dessalles et al.,Nature Physics 2025). It is composed of a cellular monolayer, such as endothelial or epithelial cell