Postdoctoral Researcher (M/F) in cell biology and neurosciences

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description A 12-month postdoctoral researcher position (renewable for an additional 12 months) is available to conduct research on the role of extracellular vesicles in the propagation of toxic proteins in Alzheimer's disease (AD) and Dementia with Lewy bodies (DLB). AD, DLB, and other related neurodegenerative disorders, share a common origin: the progressive invasion of the brain by abnormal protein deposits. The accumulation of these protein deposits in patients' brains involves cell-to-cell transfer of these abnormal proteins and their replication in a prion-like manner. This transport of abnormal proteins is notably mediated by extracellular vesicles (EVs), which are nanometric capsules secreted by all cells. The project aims to identify the molecular and functional signatures of AD- and DLB-specific EVs by combining biochemistry, cellular biology, and super-resolution microscopy approaches. - Purification and characterization of extracellular vesicles from brain tissues and cerebrospinal fluid (CSF) (biochemistry, TRPS, electron microscopy). - Quantitative analysis of subpopulations of EVs carrying toxic proteins (electron microscopy, SMLM, biochemistry). - RT-QuIC assays for the amplification of pathological aggregates (biochemistry). - Establishment of cellular models for the functional characterization of EVs carrying toxic proteins (cellular biology, electron microscopy, and super-re