Postdoctoral Researcher (M/F) — Neurobiology, Advanced Cellular Models & Near-Infrared Microglial Imaging

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description This position is hosted within the "Environmental Pollutants, Neurotoxicity, and Neuro-inflammation" team at UMR7355-INEM (Immuno-NEuro Modulation, Orléans, France). We are seeking an early-career biologist researcher with strong expertise in cellular neurobiology and advanced cellular models (murine and/or human 2D/3D cultures) to join an interdisciplinary project at the interface of biology and chemistry. The project, entitled NiNA ("Lanthanide-based Near-infrared imaging agents associated with human iPSC-derived microglia for the study of Neuroinflammation in Amyotrophic lateral sclerosis") and funded by the ANR, aims to evaluate and apply novel near-infrared (NIR) imaging agents for the improved in vitro characterization of microglial cells in Amyotrophic Lateral Sclerosis (ALS). Initial contract duration is 13 months, extendable for an additional 11 months. - Evaluate the efficacy, bioavailability, and biocompatibility of in cellulo labeling using NIR imaging agents across various 2D/3D culture systems (conventional and near-infrared fluorescence microscopy, microglial functional evaluation, immunocytochemistry, etc.). - Implement 2D/3D NIR live-cell video microscopy of labeled cells. - Perform standard analytical assays: immunocytochemistry, ELISA, multiplex assays. - Contribute closely with partners to technology transfer involving the manipulation of ALS patient-derived iPSC