IDEAS DC[15] - Design of polymeric drug delivery systems for biopharmaceuticals using green microfluidic manufacturing technologies

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Context: Biopharmaceuticals—such as proteins, peptides, and biologics—are revolutionizing modern medicine but remain challenging to formulate and deliver due to their structural fragility, instability, and susceptibility to degradation. Polymeric nanoparticle-based delivery systems offer a promising strategy to enhance stability, control release kinetics, and improve bioavailability. However, their production through conventional batch methods often suffers from poor reproducibility, limited scalability, and significant solvent and energy consumption. Objectives: This project aims to develop protein-loaded polymeric nanoparticles using green and continuous microfluidic reactor technologies. These systems will enable precise control over particle size, morphology, and release behaviour while minimizing solvent waste and energy usage. The resulting delivery platforms will provide tuneable, stable, and sustainable carriers for a wide range of therapeutic biomolecules. Expected results : Protein-loaded polymeric nanoparticles with tuneable size, morphology, and release kinetics, produced by green continuous microfluidic technology; Establishment of process–structure–property relationships for predictive design of nanoparticle-based biopharmaceutical formulations; Environmentally sustainable and scalable manufacturing protocols, reducing solvent use, waste generation, and energy consumpt