EURAXESS
Postdoctoral Position (M/F) in Synthesis and Bioconjugation
CNRS
Sponsorship not confirmed
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About the job
id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description As part of an Inserm PCSI project, the postdoctoral intern (M/F) will be responsible for synthesizing bimodal aza-BODIPY-macrocycle probes, characterizing them in solution (particularly in terms of photophysics), and bioconjugating them to an antibody targeting lymphomas and certain solid tumors. Conduct a literature review to identify the most relevant target molecules in the field. Synthesize bimodal probes and perform their full characterization (NMR, mass spectrometry, photophysical properties, etc.). Perform their bioconjugation to the target antibody, followed by studies on the resulting bioconjugates (degree of labeling (DOL), stability, affinity measurements for the targets, etc.). Actively collaborate with the other teams involved in the project. Attend monthly meetings, present results to the project team, and contribute to the valorization of the findings (writing publications, presenting results at an international conference). The recruited individual will carry out their missions within the Institute of Molecular Chemistry of the University of Burgundy (ICMUB, UMR 6302, ZRR zone), as part of the SMol team. Their work will be conducted under the Inserm project "Interdisciplinary Approaches to Oncogenic Processes and Therapeutic Perspectives: Contributions of Physics, Chemistry, and Engineering Sciences to Oncology" (BOND: Development of Bimodal Probes based on Wazabys f
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