EURAXESS
PhD Position - Quantitative Modelling of Tissue Growth
Forschungszentrum Jülich
Sponsorship not confirmed
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About the job
id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Area of research: . PHD Thesis. Job description: PhD Position - Quantitative Modelling of Tissue Growth . Are you eager to pursue a doctoral project that bridges scientific disciplines? Are you excited by complex challenges that demand interdisciplinary solutions? Are you fascinated by mechanics of growing tissues?. In a collaboration with Harvard Medical School, we recently discovered how mechanical feedback on growth of cells is regulated by the membrane potential (. www.cell.com/cell/fulltext/S0092-8674(25)01253-X . ). This work has only just begun. At the Institute for Advanced Simulation - Theoretical Physics of Living Matter (IAS-2), we want to extend this model to the third dimension and explore how mutations could effect growth, and quantitatively describe experimental observations as well as study related effects like cell competition or deformations. Your Job . You will utilize a novel, more performant, framework for tissue growth regulated by membrane potential to study biophysical questions like how cells maintain a given hight, how tissue sheets grow in three dimensions, and how competition between different celltypes play out. Your tasks will include:. Further development of an advanced simulation framework suitable for high performance computing. Explore how competition between different celltypes develops. Develop simplified analytic models for observed phenomena. An
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