Mitochondrial bioenergetic remodelling in cellular dysfunction: the role of F1Fo-ATPase and respiratory supercomplexes as targets for novel mitoprotective strategies

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description The research will identify and characterise synthetic and natural molecules capable of counteracting mitochondrial dysfunction by modulating F1FO-ATPase and preserving respiratory supercomplex organisation. Biochemical, kinetic and bioenergetic analyses in isolated mitochondria and cellular models will assess the effects of selected compounds on ATP synthesis and hydrolysis, mitochondrial respiration, membrane potential, ROS production and calcium homeostasis. Respiratory supercomplex assembly and susceptibility to mitochondrial permeability transition will also be investigated. The findings will help clarify the mechanisms of bioenergetic remodelling and identify novel mitoprotective strategies. Where to apply Website http://www.unibo.it . Requirements. Additional Information . Eligibility criteria. to apply for research grants fill out the form available at the following address: https://bandi.unibo.it/ricerca/incarichi-di-ricerca. Eligible destination country/ies for fellows: . Italy. Eligibility of fellows: country/ies of residence: . All. Eligibility of fellows: nationality/ies: . All. Website for additional job details https://bandi.unibo.it/ricerca/incarichi-di-ricerca. <h2