Postdoctoral position in Autophagy, Stress and Development M/F

id="offer-description" class="ecl-u-type-heading-2 ecl-u-mt-none ecl-u-mb-l">Offer Description Living beings are constantly subjected to environmental variations, such as temperature, which can induce stress and lead to physiological dysfunction. The implementation of relevant preventive and/or curative strategies requires improving knowledge of the regulation of stress adaptation systems, as well as developing diagnostic strategies that integrate individuals' adaptive response levels and resilience capacities. Technological advances in imaging, sequencing, and data analysis enable us to study stress responses and their effects on adaptation in animal models such as the nematode C. elegans. Our team recently developed an acute, non-lethal heat stress in C. elegans to characterize the adaptive response at the individual level (1, 2). Such a stress produces 2 populations of worms with distinct growth, fertility, and longevity characteristics (3). This project aims to identify the gene regulatory network and characterize the mechanisms underlying individual variability in stress adaptation, as well as the subsequent effects on fitness and health. Mainly based on transcriptomic analyses in C. elegans, including single-nucleus RNA-Seq, the project will combine experimental work with C. elegans and bioinformatic analyses. The postdoctoral researcher will benefit from the I2BC sequencing and bioinformatic facilities. 1) Chen, Y., Leboutet, R., Largeau, C., Zentout, S., Lefebvre, C.,